{"id":32695,"date":"2025-06-09T13:15:54","date_gmt":"2025-06-09T10:15:54","guid":{"rendered":"https:\/\/geenitestid.ee\/how-your-genes-and-diet-interact-insights-from-the-latest-fto-gene-study\/"},"modified":"2025-06-09T13:19:11","modified_gmt":"2025-06-09T10:19:11","slug":"how-your-genes-and-diet-interact-insights-from-the-latest-fto-gene-study","status":"publish","type":"post","link":"https:\/\/geenitestid.ee\/en\/how-your-genes-and-diet-interact-insights-from-the-latest-fto-gene-study\/","title":{"rendered":"How Your Genes and Diet Interact: Insights from the Latest FTO Gene Study"},"content":{"rendered":"<p data-start=\"145\" data-end=\"699\">There is increasing interest in personalized nutrition\u2014an approach that takes into account an individual\u2019s genetic background. Nutrigenetics, the science that studies the interaction between genes and nutrition, is opening new possibilities for improving health and preventing disease. In 2025, a significant study was published in the journal <em data-start=\"489\" data-end=\"515\">Clinical Nutrition ESPEN<\/em>, examining how the FTO gene variant rs9939609 influences body composition (e.g., body fat and muscle mass) depending on a person\u2019s dietary habits, especially protein and sugar intake.<\/p>\n<p>&nbsp;<\/p>\n<p data-start=\"706\" data-end=\"758\"><strong data-start=\"706\" data-end=\"758\">The FTO Gene: What Is It and Why Does It Matter?<\/strong><\/p>\n<p data-start=\"760\" data-end=\"1256\">The FTO gene (fat mass and obesity-associated gene) is one of the most researched genes linked to overweight and obesity. The specific variant rs9939609 is associated with higher body mass index (BMI) and a greater proportion of body fat. This genetic variant is quite common. However, it&#8217;s important to note that carrying this variant does not automatically lead to obesity. Genetic effects often manifest in combination with environmental factors such as diet, physical activity, and lifestyle.<\/p>\n<p>&nbsp;<\/p>\n<p data-start=\"1263\" data-end=\"1279\"><strong data-start=\"1263\" data-end=\"1279\">Study Design<\/strong><\/p>\n<p data-start=\"1281\" data-end=\"1388\"><span style=\"color: #000000;\">The study was conducted in Argentina and involved adult volunteers. The researchers analyzed participants&#8217;:<\/span><\/p>\n<ul>\n<li data-start=\"1392\" data-end=\"1436\"><span style=\"color: #000000;\"><strong data-start=\"1392\" data-end=\"1411\">Genetic profile<\/strong> (using qPCR genotyping),<\/span><\/li>\n<li data-start=\"1392\" data-end=\"1436\"><span style=\"color: #000000;\"><strong data-start=\"1439\" data-end=\"1459\">Body composition<\/strong> (measured by bioelectrical impedance), and<\/span><\/li>\n<li data-start=\"1392\" data-end=\"1436\"><span style=\"color: #000000;\"><strong data-start=\"1505\" data-end=\"1523\">Dietary habits<\/strong> (assessed through a food frequency questionnaire).<\/span><\/li>\n<\/ul>\n<p data-start=\"1576\" data-end=\"1688\">The aim was to determine whether and how diet influences the effect of the FTO gene variant on body composition.<\/p>\n<p>&nbsp;<\/p>\n<p data-start=\"1695\" data-end=\"1711\"><strong data-start=\"1695\" data-end=\"1711\">Key Findings<\/strong><\/p>\n<p data-start=\"1713\" data-end=\"1858\">Participants who carried the A allele of the rs9939609 variant (considered the risk variant) showed the following differences <span style=\"color: #000000;\">compared to others:<\/span><\/p>\n<ul>\n<li data-start=\"1862\" data-end=\"1902\"><span style=\"color: #000000;\"><strong data-start=\"1862\" data-end=\"1869\">BMI<\/strong> was on average 1.4 kg\/m\u00b2 higher.<\/span><\/li>\n<li data-start=\"1862\" data-end=\"1902\"><span style=\"color: #000000;\"><strong data-start=\"1905\" data-end=\"1928\">Body fat percentage<\/strong> was 2.5% higher.<\/span><\/li>\n<li data-start=\"1862\" data-end=\"1902\"><span style=\"color: #000000;\"><strong data-start=\"1948\" data-end=\"1964\">Visceral fat<\/strong> (fat stored around internal organs) was 0.7 units higher.<\/span><\/li>\n<li data-start=\"1862\" data-end=\"1902\"><span style=\"color: #000000;\"><strong data-start=\"2025\" data-end=\"2049\">Skeletal muscle mass<\/strong> was 1.5% lower, potentially affecting metabolic rate and physical performance.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p data-start=\"2135\" data-end=\"2176\"><strong data-start=\"2135\" data-end=\"2176\">Interaction Between Diet and Genetics<\/strong><\/p>\n<p data-start=\"2178\" data-end=\"2262\"><span style=\"color: #000000;\">The study highlighted several noteworthy interactions between diet and the FTO gene:<\/span><\/p>\n<ul>\n<li data-start=\"2266\" data-end=\"2504\"><span style=\"color: #000000;\"><strong data-start=\"2266\" data-end=\"2291\">Higher protein intake<\/strong> (e.g., from meat, fish, legumes) was associated with lower BMI and less visceral fat in individuals with the A allele. This suggests that a protein-rich diet may help offset the genetic predisposition to obesity.<\/span><\/li>\n<li data-start=\"2266\" data-end=\"2504\"><span style=\"color: #000000;\"><strong data-start=\"2507\" data-end=\"2530\">Higher sugar intake<\/strong> (especially from sugary drinks and processed foods) amplified the genetic risk\u2014BMI, body fat, and visceral fat increased significantly in A allele carriers with high sugar consumption.<\/span><\/li>\n<li data-start=\"2266\" data-end=\"2504\"><span style=\"color: #000000;\"><strong data-start=\"2718\" data-end=\"2742\">Saturated fat intake<\/strong> affected skeletal muscle mass, particularly in A allele carriers, who experienced reduced muscle mass with higher intake. Limiting saturated fats may therefore help maintain muscle mass in these individuals.<\/span><\/li>\n<li data-start=\"2266\" data-end=\"2504\"><span style=\"color: #000000;\">Certain food groups\u2014such as dairy, eggs, and fruit\u2014also showed differing effects depending on genotype.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p data-start=\"3063\" data-end=\"3089\"><strong data-start=\"3063\" data-end=\"3089\">Practical Implications<\/strong><\/p>\n<p data-start=\"3091\" data-end=\"3207\">This study underscores that genes are not destiny\u2014thoughtful dietary choices can significantly reduce genetic risks.<\/p>\n<p data-start=\"3209\" data-end=\"3221\"><span style=\"color: #000000;\">For example:<\/span><\/p>\n<ul>\n<li data-start=\"3225\" data-end=\"3331\"><span style=\"color: #000000;\">If a person knows they carry the rs9939609 A allele, they may benefit from a high-protein, low-sugar diet.<\/span><\/li>\n<li data-start=\"3225\" data-end=\"3331\"><span style=\"color: #000000;\">Reducing intake of refined sugars and sugary beverages can help prevent excessive fat accumulation.<\/span><\/li>\n<li data-start=\"3225\" data-end=\"3331\"><span style=\"color: #000000;\">Regular monitoring of body composition (e.g., through bioimpedance analysis) provides better insights than simply tracking weight.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p data-start=\"3573\" data-end=\"3587\"><strong data-start=\"3573\" data-end=\"3587\">Conclusion<\/strong><\/p>\n<p data-start=\"3589\" data-end=\"3946\">This 2025 study provides valuable scientific support for the development of nutrigenetics. It confirms that personalized nutrition\u2014tailored to both genetic makeup and dietary habits\u2014can help individuals make more effective choices for their health and fitness. Knowing your genetic predispositions allows you to balance them through smart dietary decisions.<\/p>\n<p>&nbsp;<\/p>\n<hr data-start=\"3948\" data-end=\"3951\" \/>\n<p data-start=\"3953\" data-end=\"4312\" data-is-last-node=\"\" data-is-only-node=\"\"><strong data-start=\"3953\" data-end=\"3973\">Study Reference:<\/strong><br data-start=\"3973\" data-end=\"3976\" \/>Olmedo, L., Luna, F. J., Dopazo, H., &amp; Pellon-Maison, M. (2025). Protein and total sugars intake modulate the rs9939609 single nucleotide polymorphism effect at the fat mass and obesity-associated gene on body composition. <em data-start=\"4199\" data-end=\"4229\">Clinical Nutrition ESPEN, 68<\/em>, 359\u2013367. Advance online publication. <a class=\"\" href=\"https:\/\/doi.org\/10.1016\/j.clnesp.2025.05.032\" target=\"_new\" rel=\"noopener\" data-start=\"4268\" data-end=\"4312\" data-is-last-node=\"\">https:\/\/doi.org\/10.1016\/j.clnesp.2025.05.032<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>There is increasing interest in personalized nutrition\u2014an approach that takes into account an individual\u2019s genetic background. Nutrigenetics, the science that studies the interaction between genes and nutrition, is opening new possibilities for improving health and preventing disease. In 2025, a significant study was published in&#8230;<\/p>\n","protected":false},"author":2,"featured_media":32555,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[505,506],"tags":[509,507,508],"class_list":["post-32695","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genes","category-weight-loss","tag-body-weight","tag-fto-en","tag-nutrigenetics"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>How Your Genes and Diet Interact: Insights from the Latest FTO Gene Study - myInnerGo<\/title>\n<meta name=\"description\" content=\"Discover how the FTO gene affects body fat and muscle mass, and how personalized nutrition can help reduce genetic obesity risk, based on a 2025 study.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/geenitestid.ee\/en\/how-your-genes-and-diet-interact-insights-from-the-latest-fto-gene-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"How Your Genes and Diet Interact: Insights from the Latest FTO Gene Study - 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